Phase separation of Nur77 mediates celastrol-induced mitophagy

nuri77Nur77 (also known as TR3 and NGFI-B) is nuclear receptor subfamily 4 group A member 1 (NR4A1) 1, 2, 3, 4.In general, it acts as a transcription factor localized in the nucleusNur77 is a suppressor for hepatocarcinogenesis. Gene expression data from Oncomine demonstrates that Nur77 gene expression levels were substantially lower in